MethylPro
Discover MethylPro capsules with L-methylfolate, the active form of folate, in strengths from 1 mg to 15 mg. We explain how 5-MTHF differs from folic acid, which strength suits whom and how to take it daily.Read more →
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L-methylfolate from MethylPro: strengths, formulas and who they suit
One nutrient, many strengths
MethylPro is an American supplement line built around a single nutrient: L-methylfolate, also written as 5-MTHF. That is folate (vitamin B9) in the form the body uses directly, so it needs no conversion step first. What sets this range apart is the dosing ladder: 1 mg, 2.5 mg, 5 mg, 7.5 mg, 10 mg and 15 mg. Most folate products on the shelf stop at 400 mcg, which is 0.4 mg. That gap is exactly why people search for this brand by name instead of browsing our wider folate and vitamin B9 range.
Next to the single-nutrient capsules there are combination formulas. Cofactors + L-Methylfolate adds vitamin B6, vitamin B12 and magnesium. B-Complex + L-Methylfolate puts the folate in a methylated B group. There is also a multivitamin built around 15 mg of L-methylfolate. Some strengths use Quatrefolic, a branded 5-MTHF raw material. The capsules leave out gluten, dairy, soy, corn, nuts, egg, fish, shellfish, sesame and yeast, which matters if you react to fillers.
Why we stock MethylPro
We judge a brand on three things: the form of the ingredient, the dosage, and whether the combinations make sense. MethylPro holds up on all three. The folate is 5-MTHF, not folic acid. The strengths are printed in milligrams, so you always know what you are taking. The cofactor formula pairs folate with B6, B12 and magnesium, nutrients that sit in the same metabolic pathway, rather than a long list of extras that pad the label. We buy directly from the brand, so authenticity is guaranteed, and our compliance team reviews every product before it goes live. See how we select our brands.
Who these capsules are for
Folate contributes to normal homocysteine metabolism, normal blood formation, normal amino acid synthesis, normal psychological function and normal immune function. It also helps reduce tiredness and fatigue and has a role in cell division. People choose MethylPro mainly for two reasons: they know they carry an MTHFR gene variant that slows the conversion of folic acid, or a practitioner has asked them to take folate in milligram amounts.
Be honest with yourself about which group you are in. If you simply want to top up folate, a 400 mcg product does that job well and costs less. The multi-milligram strengths are a deliberate, guided choice, not a stronger version of a daily vitamin. Two practical points worth knowing:
- Have your vitamin B12 status checked before taking high-dose folate. High folate intake can mask a B12 shortfall.
- UK national advice for anyone planning a pregnancy still names folic acid at 400 mcg daily, not 5-MTHF, because that is the form the evidence is built on.
Effects on tiredness or mood are gradual. Give any folate product two to three weeks of consistent daily use before you judge it, and keep the dose steady in that period so you can tell what is actually doing the work. MethylPro sits in the same house as the Allergy Research Group assortment, and you can compare it with the other names we carry on our brand overview.
Frequently asked questions
MethylPro is a supplement line centred on L-methylfolate, the active form of folate (vitamin B9), also written as 5-MTHF. The range covers single-nutrient capsules in several strengths plus formulas that add B vitamins, magnesium or a full multivitamin around the folate. The capsules are made without gluten, dairy, soy, corn, nuts, egg, fish, shellfish, sesame and yeast. The brand is now part of the same company as Allergy Research Group.
Folic acid is the synthetic form used in most supplements and fortified foods. Your body has to convert it in several steps before it can use it. L-methylfolate is already the converted form, so it skips that process. Some people carry a common gene variant (MTHFR) that slows the conversion, and for them the methylated form is easier to use. Folate itself does the same jobs in the body either way.
UK reference figures are far lower than the milligram strengths in this range. They are dietary reference values, not dosage advice.
| Group | Daily folate reference |
|---|---|
| Adults and children over 11 | 200 mcg |
| Considering pregnancy | 200 mcg plus 400 mcg supplement |
| First 12 weeks of pregnancy | 300 mcg plus 400 mcg supplement |
| Breastfeeding | 260 mcg |
For context, 400 mcg is 0.4 mg.
Source: British Dietetic AssociationStart with what you want alongside the folate, then pick the strength your practitioner or your own routine calls for.
| Formula | What it adds | Often chosen by |
|---|---|---|
| L-Methylfolate | Folate only | People already taking other B vitamins |
| Cofactors + L-Methylfolate | B6, B12, magnesium | People wanting the same pathway covered |
| B-Complex + L-Methylfolate | Methylated B group | People replacing a separate B-complex |
| Multivitamin + L-Methylfolate | Vitamins A, C, D3, E and more | People simplifying to one capsule |
Lower strengths let you step up gradually.
One capsule daily with food is the usual pattern, and food also softens any stomach sensitivity. Morning suits most people, because some report feeling more alert on methylfolate and would rather not have that in the evening. Take it at the same time each day so you can judge the effect fairly. Folate is water soluble, so consistency matters more than timing. For the multi-milligram strengths, follow the advice of the practitioner who suggested them.
Folate and vitamin B12 work in the same pathway, which is why the cofactor formula includes B12 and why methylated B-complex products exist. There is also a safety reason to pay attention: a high folate intake can hide the blood signs of a B12 shortfall, so the shortfall goes unnoticed. Have your B12 checked before starting high-dose folate, and browse our vitamin B12 options if you need to cover both.
Speak to your midwife or GP first. UK advice for anyone who could become pregnant is 400 mcg of folic acid daily, from before conception until week 12, and that advice names folic acid specifically because that is the form the evidence rests on. It applies even to people with an MTHFR variant. The milligram strengths in this range are much higher than that figure and are not a substitute for the standard pregnancy recommendation.
This is the most common complaint we hear, and it usually comes down to jumping straight to a high strength. Folate feeds a pathway that also needs B6, B12 and magnesium, and the response to a large step up varies a lot between individuals. Two practical approaches: start at a low strength such as 1 mg and increase slowly, or choose the cofactor formula so the supporting nutrients are present. If restlessness persists, lower the dose and check with your practitioner.
The brand was acquired by Allergy Research Group, which also owns Metabolic Maintenance and Optimox, and the websites were merged into one. According to the brand, the formulas themselves were kept as they were. For you as a buyer that means the same strengths and the same capsule base, under a wider company umbrella. We buy directly from the brand rather than through intermediaries, so what reaches you is authentic, and each batch passes our own checks plus independent lab spot-checks.
