Glucosamine is an amino sugar that naturally occurs in shellfish and crustaceans. In this supplement, it is present as hydrochloride (HCL), a commonly used form due to its stability and solubility.

Chondroitin is a structural substance that is often found in combination with glucosamine. In supplements, it is usually derived from animal sources, such as cartilage from beef or fish.

MSM stands for methylsulfonylmethane, an organic sulfur compound. "80 mesh" refers to the fineness of the powder, relating to the particle size.

Supplements such as Superflex-3 are often taken with a meal because this makes swallowing tablets easier. In addition, some ingredients, like glucosamine or MSM, may be gentler when not taken on an empty stomach.